Over patients
have been prescribed VYALEV globally†
More “On” time is possible with a 24-hour, continuous levodopa-based therapy—morning, day, and night.
*VYALEV was studied against oral immediate-release carbidopa/levodopa pills. At week 12, patients taking VYALEV achieved 2.72 hours more “On” time vs 0.97 hours more “On” time for those taking levodopa pills.
†Based on total patient numbers as of January 2025. Product name and use differ by country.
Almost 2 hours more “On” time per day without troublesome dyskinesia‡ than treatment with pills alone.*
‡Dyskinesia: Bothersome extra movements you don’t have control over.
§VYALEV replaces levodopa-containing medications and COMT inhibitors. Keep a supply of oral immediate-release carbidopa/levodopa pills with you in case you are unable to use VYALEV infusion.
COMT=catechol-O-methyltransferase.
VYALEV delivers levodopa-based therapy under the skin through a wearable pump—all day and all night.
Learn more about VYALEV by attending a free in-person or virtual event for patients and their loved ones.
VYALEV is a prescription medicine used for treatment of advanced Parkinson's disease in adults. VYALEV contains two medicines, foscarbidopa and foslevodopa.
What is the most important safety information I should know about VYALEV™ (foscarbidopa/foslevodopa)?
Do not take VYALEV if you currently take or have recently taken (within the last 14 days) a medication for depression called a nonselective monoamine oxidase (MAO) inhibitor. Ask your healthcare provider or pharmacist if you are not sure if you take an MAO inhibitor.
Tell your healthcare provider about all your medical conditions and the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. When used together, VYALEV and certain other medicines, including medications for high blood pressure, MAO inhibitors, antipsychotics, metoclopramide, and isoniazid, may affect each other and cause serious side effects.
VYALEV may cause other serious side effects. Talk to your healthcare provider before starting VYALEV and while on VYALEV if you have had or have any of the following:
Falling asleep without warning during normal daily activities. VYALEV may cause you to fall asleep while you are doing daily activities, such as driving, which may result in an accident. This can happen as late as 1 year after you start VYALEV. Do not drive or operate machinery until you know how VYALEV affects you. Tell your healthcare provider if you take medicines that can make you sleepy, such as sleep medicines, antidepressants, or antipsychotics.
Seeing, hearing, or feeling things that are not real (hallucinations). This is a common and sometimes serious side effect.
Unusual urges. Some people taking medicines for Parkinson's disease, including VYALEV, have reported problems, such as gambling, compulsive eating, compulsive shopping, and increased sex drive.
Infusion Site Reactions and Infections. Some people using VYALEV have had reactions and infections at the infusion site. This is a common and sometimes serious side effect. Remove your cannula and call your healthcare provider if you have any of the following symptoms of an infection: local spreading of redness, pain, swelling, warmth, change in color when pressing area, or fever. Take oral carbidopa/levodopa tablets until you are able to resume VYALEV.
Uncontrolled sudden movements (dyskinesia). This is a common and sometimes serious side effect. If you have new dyskinesia or your dyskinesia gets worse, tell your healthcare provider. This may be a sign that your dose of VYALEV or other Parkinson's medicines may need to be adjusted.
Heart attack or other heart problems. Tell your healthcare provider if you have had increased blood pressure, a fast or irregular heartbeat, or chest pain.
Worsening of the increased pressure in your eyes (glaucoma). The pressure in your eyes should be checked after starting VYALEV.
Do not stop using VYALEV or change your dose unless you are told to do so by your healthcare provider. Tell your healthcare provider if you develop withdrawal symptoms, such as fever, confusion, or severe muscle stiffness.
These are not all the possible side effects of VYALEV. For more information, ask your healthcare provider or pharmacist.
VYALEV (foscarbidopa and foslevodopa) injection for subcutaneous use is available in a 120 mg foscarbidopa and 2,400 mg foslevodopa per 10 mL (12 mg foscarbidopa and 240 mg foslevodopa per mL) solution.
Please see the full Prescribing Information, including Medication Guide, for additional information about VYALEV. Talk to your healthcare provider if you have questions.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.
US-VYAL-220028
If you’re aged 63 or younger without government insurance and decide with your doctor that VYALEV could be right for you, they can prescribe it now. At that point, AbbVie (the manufacturer of VYALEV) will assist both you and your doctor’s office in working toward establishing a path to coverage.
We anticipate VYALEV to be available on Medicare and other plans in the second half of 2025. This means that patients aged 64 and older are advised to wait a little longer until Medicare coverage details are determined. AbbVie is committed to working toward 100% coverage, and your doctor will update you as Medicare coverage is established.
